Protein name:
Beta-klotho (BKL;BetaKlotho) ;
Alternative:
Klotho beta-like protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct (By similarity). Interacts with FGFR1 and FGFR4.
Function:
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Subcellular Location:
Cell membrane
Single-pass type III membrane protein
Protein Attributes:
50:
MKTGCAAGSP | GNEWIFFSSD | ERNTRSRKTM | SNRALQRSAV | LSAFVLLRAV |
100:
TGFSGDGKAI | WDKKQYVSPV | NPSQLFLYDT | FPKNFSWGVG | TGAFQVEGSW |
150:
KTDGRGPSIW | DRYVYSHLRG | VNGTDRSTDS | YIFLEKDLLA | LDFLGVSFYQ |
200:
FSISWPRLFP | NGTVAAVNAQ | GLRYYRALLD | SLVLRNIEPI | VTLYHWDLPL |
250:
TLQEEYGGWK | NATMIDLFND | YATYCFQTFG | DRVKYWITIH | NPYLVAWHGF |
300:
GTGMHAPGEK | GNLTAVYTVG | HNLIKAHSKV | WHNYDKNFRP | HQKGWLSITL |
350:
GSHWIEPNRT | DNMEDVINCQ | HSMSSVLGWF | ANPIHGDGDY | PEFMKTGAMI |
400:
PEFSEAEKEE | VRGTADFFAF | SFGPNNFRPS | NTVVKMGQNV | SLNLRQVLNW |
450:
IKLEYDDPQI | LISENGWFTD | SYIKTEDTTA | IYMMKNFLNQ | VLQAIKFDEI |
500:
RVFGYTAWTL | LDGFEWQDAY | TTRRGLFYVD | FNSEQKERKP | KSSAHYYKQI |
550:
IQDNGFPLKE | STPDMKGRFP | CDFSWGVTES | VLKPEFTVSS | PQFTDPHLYV |
600:
WNVTGNRLLY | RVEGVRLKTR | PSQCTDYVSI | KKRVEMLAKM | KVTHYQFALD |
650:
WTSILPTGNL | SKVNRQVLRY | YRCVVSEGLK | LGVFPMVTLY | HPTHSHLGLP |
700:
LPLLSSGGWL | NMNTAKAFQD | YAELCFRELG | DLVKLWITIN | EPNRLSDMYN |
750:
RTSNDTYRAA | HNLMIAHAQV | WHLYDRQYRP | VQHGAVSLSL | HCDWAEPANP |
800:
FVDSHWKAAE | RFLQFEIAWF | ADPLFKTGDY | PSVMKEYIAS | KNQRGLSSSV |
850:
LPRFTAKESR | LVKGTVDFYA | LNHFTTRFVI | HKQLNTNRSV | ADRDVQFLQD |
900:
ITRLSSPSRL | AVTPWGVRKL | LAWIRRNYRD | RDIYITANGI | DDLALEDDQI |
950:
RKYYLEKYVQ | EALKAYLIDK | VKIKGYYAFK | LTEEKSKPRF | GFFTSDFRAK |
1000:
SSVQFYSKLI | SSSGLPAENR | SPACGQPAED | TDCTICSFLV | EKKPLIFFGC |
1043:
CFISTLAVLL | SITVFHHQKR | RKFQKARNLQ | NIPLKKGHSR | VFS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Mouse BKL
Polyclonal Antibody for Mouse BKL
Monoclonal Antibody for Mouse BKL
Monoclonal Antibody for Mouse BKL
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain :
Swiss Webster .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH FGFR1 AND FGFR4